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01 Jan 2019 - 29 Feb 2020 Science

2ndskin – Development of biodegradable membranes composed by nanofibres and natural extracts for wound dressing applications

A conventional dressing has the main function of covering and protecting the wound, promoting an environment on its surface in which the healing can occur quickly and completely, without the occurrence of possible infections. These dressings made of natural and / or synthetic bandages, gauze, cotton, among others, are used simply to protect the wound from contamination. In addition, traditional dressings generally adhere to the wound, which can cause a new injury when removed, and thus compromise the healing process. In addition, in the case of burns, the high frequency of renewal resulting from the short-lasting effect of the solutions used makes the recovery process painful and, sometimes, more time-consuming.
Due to the limitations that these dressings present, research and development of new dressings with additional properties that promote the wound healing process, and not just its protection, are essential. Indeed, over the years, the development of dressings has reached higher standards, based on the creation of an ideal environment at the wound site, in which accelerated healing, skin regeneration, oxygen exchange and antimicrobial properties are some of the main objectives.

These types of advanced solutions rely on the use of materials that mostly have the following characteristics: transparency, ability to keep the wound area moist, antibacterial and antifungal properties, high capacity for absorbing wound exudate and easy and painless removal. However, most solutions use glues and adhesive materials of synthetic nature that often cause allergies and inflammation around the affected area.

In addition, the dressing change process including its adhesion / removal causes damage to the wound site capable of delaying wound regeneration in addition to the pain caused to the patient. In this sense, there is a growing interest in the development of natural based solutions capable of adhering to the skin functionally without the need for glues / adhesives, effective in the treatment, but without the need to be removed, avoiding the associated pain and the delay in regeneration.

In this way, we intend to develop, in the most sustainable way possible, nanofiber membranes produced by the electrospinning process, for application in the treatment of wounds and burns on the skin.

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